Epilepsy Summary

Definitions

  • Seizure: Transient abnormal neuronal activity
  • Epilepsy: Recurring seizures
  • Focal: One hemisphere origin
  • Generalized: Bilateral origin

Key Causes

  • Structural (stroke, trauma)
  • Genetic (Dravet syndrome)
  • Infectious (TB, HIV)
  • Metabolic disorders
  • Immune-mediated

Assessment

  • Detailed history (pre/during/post ictal)
  • Neurological examination
  • Blood tests, ECG, neuroimaging
  • Specialist referral

Complications

  • SUDEP (nocturnal seizures)
  • Injuries (falls, accidents)
  • Depression & anxiety
  • Absence from work/school

Management

  • Don't start AEDs immediately
  • Safety advice (driving, bathing)
  • Lifestyle modifications
  • Specialist follow-up

Epilepsy

Seizure types, causes, assessment, and management

Overview

A seizure is the transient occurrence of signs or symptoms due to abnormal excessive or synchronous neuronal activity in the brain. Seizures can manifest as a disturbance of consciousness, behaviour, cognition, emotion, motor function, or sensation.

Key Distinction

An isolated seizure can be caused by toxic, metabolic, structural, and infectious factors and should not be confused with epilepsy. Epilepsy is a neurological disorder in which a person experiences recurring seizures.

Seizure Types

Focal Seizures

  • Originate in networks limited to one hemisphere
  • May be localized or widely distributed
  • Divided into:
    • With retained awareness
    • With impaired awareness

Generalized Seizures

  • Originate in bilaterally distributed networks
  • Can include cortical and subcortical structures
  • Divided into:
    • Motor seizures
    • Non-motor (absence) seizures

Causes of Epilepsy

A cause of epilepsy is only identified in about one third of people with the disorder. Causes include:

Structural

  • Abnormalities visible on structural neuroimaging
  • Stroke, trauma
  • Malformation of cortical development

Genetic

  • Result from known or presumed genetic mutation
  • Seizures are a core symptom
  • Examples: Dravet syndrome

Infectious

  • Result from known infection
  • Examples: tuberculosis, cerebral malaria, HIV
  • Congenital infections (Zika virus)

Metabolic

  • Result from known or presumed metabolic disorder
  • Examples: porphyria, aminoacidopathies
  • Pyridoxine deficiency

Immune

  • Result directly from immune disorder
  • Autoimmune-mediated CNS inflammation
  • Examples: anti-NMDA receptor encephalitis

Complications

SUDEP

  • Sudden unexpected death in epilepsy
  • Most common cause of epilepsy-related death in young adults
  • Rare in children
  • Significant risk factor: nocturnal seizures
  • Risk reduced with optimized seizure control

Injuries

  • Any seizure with loss of awareness can cause trauma
  • Drowning, road accidents, falls
  • In pregnancy: abdominal trauma risks

Psychological

  • Depression and anxiety disorders more common
  • Particularly with poor seizure control
  • Higher than general population

Social Impact

  • Absence from school or work more common
  • Social stigma
  • Driving restrictions

Assessment of First Seizure

History Taking

Key History Elements

  • Aura: Subjective symptoms at start (suggestive of focal epilepsy)
  • Triggers: Sleep deprivation, stress, light sensitivity, alcohol
  • Specific features: Duration, muscle activity, consciousness level
  • Post-ictal phenomena: Drowsiness, headaches, amnesia, confusion

Examination

Investigations

Blood Tests

  • Full blood count
  • Urea and electrolytes
  • Liver function tests
  • Glucose and calcium

Other Tests

  • 12-lead electrocardiogram (ECG)
  • Pregnancy test (childbearing age)
  • Brain neuroimaging if structural cause suspected

Differential Diagnosis

Conditions which may present with similar features to epilepsy include:

Cardiovascular

  • Vasovagal syncope
  • Cardiac arrhythmias

Psychological

  • Panic attacks with hyperventilation
  • Non-epileptic attack disorders (pseudoseizures)

Neurological

  • Transient ischaemic attack
  • Migraine
  • Sleep disorders
  • Movement disorders

Metabolic/Toxic

  • Medication, alcohol, or drug intoxication/withdrawal
  • Hypoglycaemia and metabolic disorders

Additional Pediatric Considerations

Management of First Seizure

Discharge Criteria

A patient presenting with a first seizure may be discharged home, accompanied by a responsible adult, if they have normal neurological and cardiovascular examination and the ECG and bloods are normal.

Referral

Medication

Patient Education and Safety

Information Provision

  • How to recognize a seizure
  • First aid measures
  • Importance of reporting further attacks

Safety Advice

  • Stop driving while awaiting specialist assessment
  • Avoid dangerous work or leisure activities
  • Shower rather than bathe
  • School safety considerations

Lifestyle Factors

  • Avoid sleep deprivation
  • Limit or avoid alcohol
  • Avoid social drugs
  • Manage stress

Seizure Type Characteristics

Seizure Type Key Characteristics Duration Post-ictal State
Tonic Short-lived, abrupt, generalized muscle stiffening (may cause fall) Less than 1 minute Rapid recovery
Generalized Tonic-Clonic Generalized stiffening and rhythmic jerking, urinary incontinence, tongue biting 1-3 minutes Drowsiness, confusion, amnesia
Absence Behavioral arrest, staring spells 10-20 seconds None
Atonic Sudden loss of muscle tone (drop attacks) Seconds Rapid recovery
Myoclonic Brief, shock-like involuntary single or multiple jerks Seconds None